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Although no substantial dissimilarities have been present in tyrosine hydroxylase activity and expression, brain tissue amounts of 3,four-dihydroxyphenylalanine ended up threefold larger in ?2A- and ?2C-adrenoceptor KO mice. Brain tissue amounts of dopamine and noradrenaline have been appreciably greater in ?2A and ?2CKOs compared with WT [WT: two.
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